Robert Frost :: essays research papers

Robert Frost Robert Frost (1874-1963) was one of the best of provincial New England's twentieth century peaceful writers. Ice distributed his first books in Great Britain during the 1910s, however he before long became in his own nation the most read and continually anthologized artist. Ice was granted the Pulitzer Prize multiple times. Robert Frost was conceived in San Francisco, California on March 26, 1874. His dad, a columnist and neighborhood lawmaker, kicked the bucket when Frost was eleven years of age. His Scottish mother continued her vocation as a teacher to help her family. The family lived in Lawrence, Massachusetts, with Frost's fatherly granddad. In 1892 Frost moved on from a secondary school and went to Dartmouth College for a couple of months. Throughout the following ten years he held various employments. In 1894 the New York Independent distributed Frost's sonnet "My Butterfly" and he had five sonnets secretly printed. In 1895 he wedded a previous classmate, Elinor White; they had six youngsters. Ice filled in as an instructor and kept on composing and distribute his sonnets in magazines. From 1897 to 1899 Frost learned at Harvard, yet left without accepting a degree. He moved to Derry, New Hampshire, working there as a shoemaker, rancher, and instructor at Pinkerton Academy and at the state ordinary school in Plymouth. In 1912 Frost sold his homestead and took his significant other and four small kids to England. There he distributed his first assortment of sonnets, â€Å"A Boy’s Will† (1913) trailed by â€Å"North Boston† (1914), which increased global notoriety. The assortment contains a portion of Frost's most popular sonnets: "Mending Wall," "The Death of the Hired Man," "Home Burial," "After Apple-Picking," and "The Wood-Pile." In the wake of coming back to the US in 1915 with his family, Frost purchased a homestead close Franconia, New Hampshire. He showed later at Amherst College (1916-38) and Michigan colleges. In 1916 Frost was made an individual from the National Institute of Arts and Letters. Around the same time showed up his third assortment of stanza, â€Å"Mountain Interval†, which contained such sonnets as "The Road Not Taken," "Birches," and "The Hill Wife." Frost's pictures - woods, stars, houses, creeks, - are typically taken from regular day to day existence. With his practical way to deal with his subjects, perusers thought that it was anything but difficult to follow the artist into more profound certainties, without being troubled with precision. In 1920 Frost bought a homestead in South Shaftsbury, Vermont, close Middlebury College. His significant other kicked the bucket in 1938 and he lost four of his youngsters.

UCCs Effect On International Commerce Essay Example | Topics and Well Written Essays - 750 words

UCCs Effect On International Commerce - Essay Example The third article accommodates the exchanges in business papers, for example, debatable instruments and promissory notes (Hinkelman and Shippey, 2004). Different arrangements are additionally significant in exchange since they give rules on issues, for example, mass exchanges, made sure about exchanges and dealings in speculation protections, for example, stocks and bonds. The UCC applies to national exchange, yet would have constructive outcomes whenever applied to worldwide business. The UCC is intended for brisk references on laws with respect to arrangement of business contracts, master examination of the effect of different business exchanges and simple treatment of court choices in regards to debates exuding from exchange (Hinkelman and Shippey, 2004). The primary impact of UCC on global trade is assistance of worldwide exchanges in the offer of merchandise. UCC will guarantee that cross-fringe shippers have confidence in offer of merchandise contracts because of the consistenc y in the administrative laws. The expansion in outside direct speculations and development in innovation has prompted crisis of new sort of business exchanges that require a uniform type of authoritative understandings and lawful security (Hinkelman and Shippey, 2004). For example, innovation has permitted organizations to sell advanced items across national fringes and global organizations to list their stocks in various national stock trade markets. For this situation, uniform business code would be useful in encouraging worldwide trade (Hinkelman and Shippey, 2004). Uniform business code in the worldwide trade would be helpful in checking examples of universal financial wrongdoings, for example, illegal tax avoidance and dumping. The UCC would be equipped for offering lawful rules that address issues identifying with preoccupation of payload in the high oceans, falsifying and deceitful protection asserts that are basic in sea exchange. UCC will be helpful in worldwide offering fo rms (Hinkelman and Shippey, 2004). The arrangements will be significant in guaranteeing consistency of worldwide tenders, for example, government tenders. This will guarantee that contracting parties get top notch benefits because of sincere trust necessities and straightforwardness of the procedure (Hinkelman and Shippey, 2004). UCC will facilitate the global exchange of assets through making uniform necessities in bank assortments, settlements of money related protections and store moves among the universal exchange members. UCC will make lawful execution commitment to exchanges including a made sure about gathering. The code of business will control the exchanges of dematerialized protections. For this situation, the last speculators in the venture protections will have satisfactory security qualification and option to get any profits collecting from their responsibility for security. Article 8 disintegrates the security rights in this way leasers are shielded from the chance of the financial specialist of moving such stake without educating the lender who has some enthusiasm for the concerned security (Hinkelman and Shippey, 2004). The effect of making sure about the exchanges is to give an alleviation to the loan specialist through a security enthusiasm for the guarantee and a confirmation in the default by the acquiring party. In many states, the made sure about exchanges utilize individual property, apparatuses and immaterial property as the security on account of default. This code will encourage liquidation settlements along these lines encouraging global exchange exchanges (Hinkelman and Shippey, 2004). Articles 5 of the UCC give rules on the issuance of letters of credit by monetary establishments. The letters of credit

Refreshment

Refreshment Last week, I spoke a little about Camp Kesem, one of the many student organizations at MIT and one that dedicates a lot of time and effort into putting together a free summer camp for kids whose parents have cancer. As I mentioned, the other camp counselors and I have been trying hard to raise enough money for camp this year. Weve organized several on-campus events, including bake sales and Stuff My Cups; now, were involved in something even bigger: Pepsi Refresh. The Pepsi Refresh Project is, as you might guess, from Pepsi :) Haha, I know duh. But yeah, its from Pepsi, and its basically an initiative to encourage people to make a positive difference in the world. Past grant recipients have used the money to fund research on spinal muscular atrophy, to send care packages to troops overseas, and to buy library books for elementary school children, among other things. Its nothing less than extraordinary. We CK-ers would like to use the money to send a larger group of kids to camp. There are a thousand project entries, and right now, were in 23rd place!! If we become one of the top two vote-getters in the $250,000 category, then every branch of Camp Kesem gets $10,000 including Camp Kesem MIT :) Right now, $55,000 will send 60 kids to camp; $10,000 more will enable us to reach out to even more children ‚ô• Voting runs through May 31 and you can vote twice every single day: once through a Pepsi account and once if you add the Pepsi Refresh app on Facebook. Heres the MIT Camp Kesem Pepsi Refresh page, and heres a form you can fill out if youre willing to create a Pepsi Refresh account and help out but will probably forget to vote every day (haha, like me). If you fill out the form, then we can actually vote FOR you, which, according to Pepsi, is entirely legitimate yayy. So anyway thats my pitch for Camp Kesem. But I also want to encourage you all to glance about your community and see what you can do to make it better. I think one of the most important things Ive learned in my time here at MIT is that its entirely okay to not know everything or to just have an idea without a clue regarding its implementation. By working with others, seeking outside help, and simply being enthusiastic about the cause you support, you can learn and achieve so, so much. And youll love it all the way through.

History of Neon Signs Georges Claude and Liquid Fire

The theory behind neon sign technology dates back to 1675, before the age of electricity, when the French astronomer Jean Picard* observed a faint glow in a mercury barometer tube. When the tube was shaken, a glow called barometric light occurred, but the cause of the light (static electricity) was not understood at that time. Even though the cause of barometric light was not yet understood, it was investigated. Later, when the principles of electricity were discovered, scientists were able to move forward towards the invention of many forms of lighting. Electric Discharge Lamps In 1855, the Geissler tube was invented, named after Heinrich Geissler, a German glassblower and physicist. The importance of the Geissler tube was that after electrical generators were invented, many inventors began conducting experiments with Geissler tubes, electric power, and various gases. When a Geissler tube was placed under low pressure and an electrical voltage was applied, the gas would glow. By 1900, after years of experiments, several different types of electric discharge lamps or vapor lamps were invented in Europe and the United States. Simply defined the electric discharge lamp is a lighting device consisting of a transparent container within which a gas is energized by an applied voltage, and thereby made to glow. Georges Claude - Inventor of the First Neon Lamp The word neon comes from the Greek neos, meaning the new gas. Neon gas was discovered by William Ramsey and M. W. Travers in 1898 in London. Neon is a rare gaseous element present in the atmosphere to the extent of 1 part in 65,000 of air. It is obtained by liquefaction of air and separated from the other gases by fractional distillation. The French engineer, chemist, and inventor Georges Claude (b. Sept. 24, 1870, d. May 23, 1960), was the first person to apply an electrical discharge to a sealed tube of neon gas (circa 1902) to create a lamp. Georges Claude displayed the first ​neon lamp to the public on December 11, 1910, in Paris. Georges Claude patented the neon lighting tube on Jan. 19th, 1915 - U.S. Patent 1,125,476. In 1923, Georges Claude and his French company Claude Neon, introduced neon gas signs to the United States, by selling two to a Packard car dealership in Los Angeles. Earle C. Anthony purchased the two signs reading Packard for $24,000. Neon lighting quickly became a popular fixture in outdoor advertising. Visible even in daylight, people would stop and stare at the first neon signs dubbed liquid fire. Making a Neon Sign Hollow glass tubes used to make neon lamps come in 4, 5 and 8 ft lengths. To shape the tubes, the glass is heated by lit gas and forced air. Several compositions of glass are used depending on the country and supplier. What is called Soft glass has compositions including lead glass, soda-lime glass, and barium glass. Hard glass in the borosilicate family is also used. Depending on the glass composition, the working range of glass is from 1600 F to over 2200F. The temperature of the air-gas flame depending on the fuel and ratio is approximately 3000F using propane gas. The tubes are scored (partial cut) while cold with a file and then snapped apart while hot. Then the artisan creates the angle and curve combinations. When the tubing is finished, the tube must be processed. This process varies depending on the country; the procedure is called bombarding in the US. The tube is partially evacuated of air. Next, it is short-circuited with high voltage current until the tube reaches a temperature of 550 F. Then the tube is evacuated again until it reaches a vacuum of 10-3 torr. Argon or neon is backfilled to a specific pressure depending on the diameter of the tube and sealed off. In the case of an argon-filled tube, additional steps are taken for the injection of mercury; typically, 10-40ul depending on tube length and climate it is to operate in. Red is the color neon gas produces, neon gas glows with its characteristic red light even at atmospheric pressure. There are now more than 150 colors possible; almost every color other than red is produced using argon, mercury, and phosphor. Neon tubes actually refer to all positive-column discharge lamps, regardless of the gas filling. The colors in order of discovery were blue (Mercury), white (Co2), gold (Helium), red (Neon), and then different colors from phosphor-coated tubes. The mercury spectrum is rich in ultraviolet light which in turn excites a phosphor coating on the inside of the tube to glow. Phosphors are available in most any pastel colors. Additional Notes Jean Picard is better known as the astronomer who first accurately measured the length of a degree of a meridian (longitude line) and from that computed the size of the Earth. A barometer is a device used to measure atmospheric pressure. Special thanks go to Daniel Preston for providing technical information for this article. Mr. Preston is an inventor, an engineer, a member of the technical committee of the International Neon Association and the owner of Preston Glass Industries.

ESL Vocabulary Words for Body Movements

Fahrenheit 451 and Salamander Reading Comprehension Free Essays

Fahrenheit 451 The Hearth and the Salamander Reading Comprehension Questions 1) The country is not at peace. The country defends itself no matter what. Jets fly across the sky, meaning there is a war. We will write a custom essay sample on Fahrenheit 451 and Salamander Reading Comprehension or any similar topic only for you Order Now 2) Captain Beatty seems to be directing Montag’s remarks at the fire station. Montag’s comments make the other firemen suspicious because he talks about how all firemen resembles a mirror image of him, and asks why don’t they prevent fires instead of burning the books. 3) The alarm at the old woman’s house is so â€Å"inconvenient† because usually before the firemen arrived at the house and the occupants had already been arrested and taken away. However, in this call, she was still at home. 4) Beatty says that none of the books agree with each other, many are lies about people who never actually lived, and it’s against the law for people to have books. 5) Montag is sick to his stomach because Mildred tells him that Clarrise’s family had moved away and she had got it by a car. Mildred had forgotten to tell Montag four days ago, but she couldn’t tell him if she was sure or not. 6) The ever-increasing speed of society affected books according to Beatty by people watching things on the television, short version of books, and the advancement of technology. ) The advancement in technology over books was the most important thing in society. Such as classics cut to fifteen or twenty minute shows, politics being two sentence headliner, and books being cut right to the information. 8) The objections of minority groups affected books by minority groups being offensive by certain types of literature, leading to cens orship. 9) Comics, confessions, and trade journals are left for people to read. 10) Beatty made a unspoken â€Å"deal† that if Montag had handed over the books, the whole incident would be looked over. How to cite Fahrenheit 451 and Salamander Reading Comprehension, Essay examples

Love Poetry Essay Example For Students

Love Poetry Essay For my literature essay I have decided to write about three poems each showing a different view of love. The first poem I chosen is The passionate shepherd to his love written by Christopher Marlowe (1564-1593), The nymphs reply to the shepherd by Sir Walter Ralegh (1552-1618) and finally Bredon Hill written A. E. Housman (1859-1936). I have chosen these three poems because each of them have a different view of love and what each poet is prepared to do for love. The third poem I have chosen is in reply to the second poem and it takes a very different view of love in how it isnt always good and how it can fade. Some of the poems are realistic but others are very romanticized. Using these three poems I am going to contrast the view of love taken by each poet. The first poem I have choosen to comment on is The Passionate Shepherd To His Love written by Christopher Marlowe. In this poem we see a very romanticized view of how this poet sees love. This poem focusses on the things that the poet can give his love but if you look closely he has promised her things which are impractical and that will soon fade or break. Examples of this are fragrant posies, fair lined slippers, bed of roses and gown made of the finest wool. The poet has done this to show the girl, if she will love him, that their life will prefect and she can have all this but only if she loves him. All through this poem we can see that the poet focusses on nature and that everything he promises her is beautiful and natural. The poet has done this because he wants to keep with the rustic background and show her he is offering her all he can. The poet uses a lot of imagery, he includes lots of adjectives when he is describing things examples of this are craggy and melodious. These create a very personal view of how he sees love and helps the reader get nto the way the poet is thinking. By picking out lots of natural things the poet is showing the love is natural. The view of love in this poem is rather impractical as the poet only sees the good things and isnt aware of the problems that they may meet along the way. However, this is not the view taken when Sir Walter Ralegh replies to this poem in The Nymphs Reply To The Shepherd. This is the girl replying to the shepherd. You can see that she has taken a very realistic view love and tells the shepherd of all the problems they could face if they were together. Sir Walter Ralegh has taken all the things the shepherd has promised the girl and shows him how they could fade or die just like their love could. The poet has choosen negative words in this poem for example, rotten, cold and rivers rage. This poem is not what most people would call a love poem as it doesnt share the romanitcized view many of the other poets had around the time it was written. The girl then goes on to say that if these things could last she would agree to be with but since they do not she says she cant love him. Most typical love poems would have the girl say yes but in this oem it has shown that love is not all sweetness and happiness but that it can fade or even die in some cases. When you compare this poem to what it is replying to its seems very negative but infact it is because the poem written by Christopher Marlowe is very romanticized that is appears like this. Moving onto my third and final poem which is Bredon Hill written by A. E. Housman we see that it is a typical love poem about a young couple but at the end there is a twist. This poem tells us the story of a young couple who plan to marry but before they can the young girl dies. .u61ffd8a85a1110fefbf04088fcdd88c0 , .u61ffd8a85a1110fefbf04088fcdd88c0 .postImageUrl , .u61ffd8a85a1110fefbf04088fcdd88c0 .centered-text-area { min-height: 80px; position: relative; } .u61ffd8a85a1110fefbf04088fcdd88c0 , .u61ffd8a85a1110fefbf04088fcdd88c0:hover , .u61ffd8a85a1110fefbf04088fcdd88c0:visited , .u61ffd8a85a1110fefbf04088fcdd88c0:active { border:0!important; } .u61ffd8a85a1110fefbf04088fcdd88c0 .clearfix:after { content: ""; display: table; clear: both; } .u61ffd8a85a1110fefbf04088fcdd88c0 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u61ffd8a85a1110fefbf04088fcdd88c0:active , .u61ffd8a85a1110fefbf04088fcdd88c0:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u61ffd8a85a1110fefbf04088fcdd88c0 .centered-text-area { width: 100%; position: relative ; } .u61ffd8a85a1110fefbf04088fcdd88c0 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u61ffd8a85a1110fefbf04088fcdd88c0 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u61ffd8a85a1110fefbf04088fcdd88c0 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u61ffd8a85a1110fefbf04088fcdd88c0:hover .ctaButton { background-color: #34495E!important; } .u61ffd8a85a1110fefbf04088fcdd88c0 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u61ffd8a85a1110fefbf04088fcdd88c0 .u61ffd8a85a1110fefbf04088fcdd88c0-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u61ffd8a85a1110fefbf04088fcdd88c0:after { content: ""; display: block; clear: both; } READ: Poetry Presentation Outline EssayThe oet then goes on to say they would lie on Bredon Hill in the summer and listen to the birds and the church bells ringing while they thought of their future. In stanza 3 they ignore the bells calling them to church sunday. Then the poet goes on to say how the bells chiming made him think of their wedding in the coming spring and how the bells will peal in celebration on that day. But it is Stanza 5 when the girl dies the poet expresses this in the metaphor My love rose up so early/ And stole out unbeknown/ And went to church alone. This time the bell that is calling him to church is one of great sorrow. The poet starts of very happy but as you move the end of the poem the mood changes as the poet loses his lover. A. E. Houman uses the image of the bells to show how even they can tell a story if you listen closely to them. In stanza 3 they are sounding happy and are celebrating but in stanza 7 the bells tell a different story, they no longer are celebrating but mourning a death. He continues to say that the people are congregated here for a funeral but infact it should be for their wedding. In stanza 6, the final verse the poet refers to the bells one last time and this time he replies to them by aying, I hear you I will come. This reply could mean one of two things. Firstly that he will go to church on a sunday or more likely that he is going to take his own life so he can reunitied with his lover in death. This is a typical love story were one of the young couple dies and the other partner takes their own life to be with them for example Romeo and Juillet. In this poem you can sense the pain this young man is feeling and it is clearly seen. The poet has used simple language but the message they are trying to convery is converyed clearly. Now that I have looked at each of the poems inturn and discussed how hey protray love I can see that I have picked three very different poems. In each of them the view is very different and is effective in their own way. I feel that both Brendon Hill and The passionate Shepherd to His Love are typical love poems but The Nymphs Reply To The Shepherd is very realisitc as it shows that love is not all beautiful and golden but that it can fade and will be lost. The poet has shown that you dont need to offer expensive gifts to have love. Each poem has its own way of getting its point across and I think that each of them did in their own way. The first wo poems I looked at were written around the same period but the third poem was written some time later. This is seen very clearly as the first two take a different view on love compared to the last poem. All three poems are similar in that they tell a love story and show how great love can be but the second and third poem go futher and say that love isnt always great and that there will be many problems. One theme which is common in all three poems is nature. They all talk about nature and the seasons. Some of them are not very graphic but they have a lot of feeling and emotion in them.

Tale Of Two Cities Essays - English-language Films,

Tale of Two Cities In the fictitious novel Tale of Two Cities, the author, Charles Dickens, lays out a brilliant plot. Charles Dickens was born in England on February 7, 1812 near the south coast. His family moved to London when he was ten years old and quickly went into debt. To help support himself, Charles went to work at a blacking warehouse when he was twelve. His father was soon imprisoned for debt and shortly thereafter the rest of the family split apart. Charles continued to work at the blacking warehouse even after his father inherited some money and got out of prison. When he was thirteen, Dickens went back to school for two years. He later learned shorthand and became a freelance court reporter. He started out as a journalist at the age of twenty and later wrote his first novel, The Pickwick Papers. He went on to write many other novels, including Tale of Two Cities in 1859. Tale of Two Cities takes place in France and England during the troubled times of the French Revolution. There are travels by the characters between the countries, but most of the action takes place in Paris, France. The wineshop in Paris is the hot spot for the French revolutionists, mostly because the wineshop owner, Ernest Defarge, and his wife, Madame Defarge, are key leaders and officials of the revolution. Action in the book is scattered out in many places; such as the Bastille, Tellson's Bank, the home of the Manettes, and largely, the streets of Paris. These places help to introduce many characters into the plot. One of the main characters, Madame Therese Defarge, is a major antagonist who seeks revenge, being a key revolutionist. She is very stubborn and unforgiving in her cunning scheme of revenge on the Evermonde family. Throughout the story, she knits shrouds for the intended victims of the revolution. Charles Darnay, one of whom Mrs. Defarge is seeking revenge, is constantly being put on the stand and wants no part of his own lineage. He is a languid protagonist and has a tendency to get arrested and must be bailed out several times during the story. Dr. Alexander Manette, a veteran prisoner of the Bastille and moderate protagonist, cannot escape the memory of being held and sometimes relapses to cobbling shoes. Dr. Manette is somewhat redundant as a character in the novel, but plays a very significant part in the plot. Dr. Manette's daughter, Lucie Manette, a positive protagonist, is loved by many and marries Charles Darnay . She is a quiet, emotional person and a subtle protagonist in the novel. One who never forgot his love for Lucie, the protagonist Sydney Carton changed predominately during the course of the novel. Sydney , a look-alike of Charles Darnay, was introduced as a frustrated, immature alcoholic, but in the end, made the ultimate sacrifice for a good friend. These and other characters help to weave an interesting and dramatic plot. Dr. Manette has just been released from the Bastille, and Lucie, eager to meet her father whom she thought was dead, goes with Mr. Jarvis Lorry to bring him back to England. Dr. Manette is in an insane state from his long prison stay and does nothing but cobble shoes, although he is finally persuaded to go to England. Several years later, Lucie, Dr. Manette, and Mr. Lorry are witnesses at the trial of Charles Darnay. Darnay, earning his living as a tutor, frequently travels between England and France and is accused of treason in his home country of France. He is saved from being prosecuted by Sydney Carton, who a witness confuses for Darnay, thus not making the case positive. Darnay ended up being acquitted for his presumed crime. Darnay and Carton both fall in love with Lucie and want to marry her. Carton, an alcoholic at the time, realizes that a relationship with Lucie is impossible, but he still tells her that he loves her and would do anything for her. Darnay and Lucie marry each other on the premises of the two promises between Dr. Manette and Darnay. Right after the marriage, while the newlyweds are on their honeymoon, Dr. Manette has a relapse and cobbles shoes for nine days straight. France's citizens arm themselves for a revolution and, led by the Defarges, start the revolution by raiding the Bastille. Shortly before the start of the revolution, the Marquis runs over a child in the streets of Paris. He is assassinated soon after by Gaspard, the child's father, who is

Edward Estlin Cummings essays

Edward Estlin Cummings essays Edward Estlin Cummings was an American poet, who was one of the most radically experimental and inventive writers of the 20th century. Some distinctive feature of Cummings's poetry is the abandonment of uppercase letters and his use of grammar, sentence structure, and punctuation. He had his own unique style of writing unlike any other writer in history. E. E. Cummings was born in Cambridge, Massachusetts on October 14, 1894. Early in his life, Cummings parents, Edward and Rebecca Clarke Cummings, encouraged him to develop his creative writing skills. In 1911, Cummings entered Harvard College, where his father was a teacher, specializing in Greek and other languages. In 1916 Cummings receives MA from Harvard Graduate School of Arts and Sciences. After Harvard, Cummings moved to New York City to work for a mail-order publishing company. In 1917 Cummings volunteered to serve in the Norton-Harjes Ambulance group in France. During Cummings service, he met William Slater Brown, who becomes his life long friend. They are both assigned to ambulance duty on Noyon sector. Later Browns letters home aroused suspicions in the French army censor. On September 21, 1917, Brown was arrested along with Cummings, who refused to separate himself from Brown. They were both imprisoned for three months at a French detention camp. In 1922, Cummings wrote a book about his experience in the detention camp called, The Enormous Room. After the First World War was over, Cummings went to Paris to study art. When he returned home to New York in 1924, Cummings found himself a celebrity for the Enormous Room, Tulips, and Chimneys. In 1931, Cummings published a collection of drawings and paintings titled CIOPW, (an acronym for the materials he used: charcoal, ink, oil, pencil, and watercolors) and had many individual show in New York over the next three decades. Over the next few years Cummings published many other books of poetry. He pub...

Black Americans suffers ater war Essay Example | Topics and Well Written Essays - 500 words

Black Americans suffers ater war - Essay Example ime differences between the pre-war and post-war rights of the Black Americans were that after the war, they were able to cast vote, hold their own offices and also go to schools. In addition to these three differences, societal norms and practices had also altered in favor of the Black Americans. In 1867, one of the most integrated Southern cities, New Orleans distorted the long-prevailed segregation in the street cars, elected 95 black representatives and 32 black senators for the state from 1868 till 1896. Thus, more Black Americans were in politics than ever before. â€Å"African Americans so dominated the catering business that they formed the United Public Waiters’ Mutual Beneficial Association† (â€Å"After the Civil War†). Moreover, interracial marriages were also legalized. Nevertheless, life of the Black Americans in the South was yet quite imperfect in spite of all these changes. In the days of Reconstruction, opportunities for the black Americans were limited by the Black Codes according to which, Black Americans that went into professions other than agriculture were supposed to pay taxes. The Black Americans were also not allowed to possess guns or rent the land. Immediately following the Civil War, numerous anti-black agencies had surfaced one of which was the Ku Klux Klan. Lynching is the term used to refer to the illegal execution of an individual that is accused of a crime by the mob. This was originally used by White Americans to punish the Black slaves. Not just the slaves, even members of the White community that expressed their consent against lynching had had their lives put in risk. Alton Observer’s Editor Elijah Parish Lovejoy was assassinated by the White Americans on 7 November 1837 due to his criticism for lynching and consent for the eradication of slavery (â€Å"Lynching†). In the post-war era, lynching was frequently used by the Ku Klux Klan to execute the Black Americans. The period between 1868 and 1871 was when the lynching

New Public Management in the Governance and Management of the NHS Case Study

New Public Management in the Governance and Management of the NHS - Case Study Example The UK is widely viewed as a lead reformer of New Public Management, with evidence of a rapid and radical reform programme introduced across the public sector in the 1980s and 1990s. It is undeniable that the UK has had a leading role in the development of NPM. McLaughlin and Osborne (2002) even suggest that there is an argument to claim that the UK was the birthplace of NPM. The adversarial style of its implementation is also a key feature of the UK model (Clark 2000) and this is linked to the political ideology of the Conservative Government, led by Margaret Thatcher, and the constitutional framework that dictates the pace of change. The UK had been viewed as managerially inept (Kingdom 2000: 34) before NPM. In the UK in the 1980s it is easy to regard NPM as a direct result of Thatcherism. There is a strong argument that the success in embedding NPM in the UK can be attached to the drive from the center, and significantly the Prime Minister. However it is still developing, following the change in government in 1997. What seems to have occurred is that the emphasis of the debate was driven initially by ideology but overtaken with debate about improving the management of the public sector, regardless of ideology. The election of the New Labour Government in 1997 could have been expected to have impacted upon the direction of the NPM movement in the UK. However many of the pre-existing agendas have continued and in some cases accelerated, for example, the move to more private finance of services in the public sector. The election of the New Labour Government in 1997 did not reverse the reform programme, although it did refocus around their policies of the modernization agenda (Bovaird and Loffler 2003). Hood (1991) (Hughes 2003: 4) coined the term New Public Management (NPM). The key concepts of NPM emerged as a challenge to traditional public administration in the 1980s In the 1980s there were serious economic difficulties that affected the western capitalized states, resulting in enormous pressures on government spending and this spurred debate on the review of public sector spending across the countries in a move to reduce the spiraling costs.     

Drug Discovery and Development Processes

Drug Discovery and Development Processes INTRODUCTION The human body is a miracle but it is also extremely vulnerable. Many illnesses and disorders are still untreatable. Fortunately science is always evolving. It is unravelling more and more secrets about how our body works and which process is occurring in conditions of sickness or health. The challenge is to use our scientific knowledge to discover new, innovative drugs, a new hope for the patients all over the world. Drug Designing or Drug Discovery and Development is an inventive process of finding new medications based on understanding of the biological target. Vast majority of drugs are small molecules designed to bind, interact and modulate the activity of specific biological proteins. These proteins which may also be receptors bind to and interact with other molecules to perform the numerous functions required for the maintenance of life. In many illnesses, one or more proteins or receptors in the body are not working correctly. That is what the scientists try to detect. If they discover which proteins or receptors cause an illness then these same proteins become the target for the development of a new drug. Thus, the target is the naturally existing cellular or molecular structure involved in the pathology of interest that the drug-in-development is meant to act on. Drugs work by interacting with target molecules (receptors) in our bodies and altering their activities in a way that is benef icial to our health. In some cases, the effect of a drug is to stimulate the activity of its targets (an agonist) while in other cases the drug blocks the activity of its target (an antagonist). DRUG DISCOVERY PROGRAMME A drug discovery programme initiates because of a disease or a clinical condition for which a suitable medical product is not available. It is this unmet clinical need which is the underlying driving motivation for the project. Developing a drug from an original idea to the launch of the finished product is a very labor-intensive, time consuming and expensive procedure which can take over 14 years to complete. Target-based drug discovery starts with a thorough understanding of the disease mechanism and the role of enzymes, receptors or proteins within the disease pathology. The initial research would include experimental procedures to identify proteins responsible of the disease and generation a hypothesis that the inhibition or activation of those protein or pathway will result in a therapeutic effect in a disease state. The outcome is the selection of a target which may require further validation prior to progression into the lead discovery phase in order to justify a drug discovery effort. During lead discovery an intensive search ensues with the help of a technique called High Throughput Screening (HTS) to find a drug-like molecule or biological therapeutic, typically termed as a development candidate, that will progress into the preclinical, and if successful, into clinical development and ultimately be a marketed medicine. Drug discovery process from target identification and validation through to filing of a compound and the approximate timescale for these processes. FDA: Food and Drug Administration; IND: Investigational New Drug; NDA: New Drug Application. DRUG TARGETS One of the most important steps in developing a new drug is target identification and validation. A target is a broad term which can be applied to a range of biological entities such as proteins, genes and RNA. A drug target is a key molecule involved in a particular metabolic or signal transduction pathway that is specific to a disease condition or a specific disease. Knowing the cellular targets of drugs is crucial if the process of drug discovery is to be made more efficient. Identifying the full spectrum of targets associated with a bioactive small molecule can lead to faster optimization, understanding of off-target side effects and the ability to minimize possible toxicities early on in the process. It is vital to have as much evidence as possible to support a target of choice before investing more resources in the target. Good targets share several features: involvement in a crucial biological pathway; distinction from any previously known target; functionally and structurally characterized; and druggable. A ‘druggable’ target is accessible to the putative drug molecule and upon binding elicits a biological response which can be measured both in vitro and in vivo. It also needs to be efficacious, safe, meet clinical and commercial needs. When searching for novel drug targets, candidates can be assessed according to how many of these features they have, as well as participation in a biological process critical to the disease. Identification of the target is followed by its validation which a process of physiologically, pathologically and pharmacologically evaluating a biomolecule. It might be performed at the molecular, cellular or whole animal level. The potential drug target is then subject to high-throughput screening against a library of drug-like compounds or to rational drug designin g. However, the term ‘drug target’ itself has several limitations. The following points should be kept in mind: First, a drug is disease-dependent, that is, every target is involved in a spectrum of diseases. Second, most human diseases are rather complicated and involve a number of risk factors, so there clearly are many different targets with respect to a specific disease. Targeting a specific target could not conceivably cure a disease. Third, there are many drugs targets the same target and one drug may have more than one target. The relationship between a drug and its target is not one-to-one but many-to-one. According to whether there are drugs available, a drug target can be classified into two classes: established drug targets and potential drug targets. The former are those for which there a good scientific understanding, supported by a lengthy publication history regarding both how the target functions in normal physiology and how it is involved in human pathology. Furthermore, there are many drugs targeting this target. The latter are those biomolecules whose functions are not fully understood and which lack drugs targeting them. Potential targets suggest directions for complete new drug research. At present, the most frequent protein targets for which successful drugs have been developed include proteases, kinases, GPCRs and nuclear hormone receptors. GPCRs and enzymes represent the most important classes of proteins for drug discovery. According to the DrugBank database, there are 435 effect-mediating drug targets in human genome. These structures are targets of 989 unique drugs, through 2,242 drug-target interactions. The dataset shows that receptors make up the largest group of drug targets: 193 proteins (44%) of the human drug targets) are receptors, and 82 (19%) of these are G protein-coupled receptors (GPCRs). In overall dataset, ~36% of drug targets are GPCRs. Ligand-gated ion channels are second largest receptor target class followed by receptor tyrosine kinases at the third place. Enzymes are the second largest group of target proteins in the human genome, comprising 29% of all human drug targets. Hydrolases are the most common class of enzymatic drug targets, comprising 49% of all human enzyme drug targets followed by oxidoreductases and transferases comprising 27% and 19% respectively. In addition, the majority (78%) of the enzyme targets are soluble proteins and not membrane-associated proteins. E.g.; cyclooxygenase 1 and cyclooxygenase 2, which belong to the oxidoreductase family are targeted by acetylsalicylic acid (aspirin).

Cell Bio Lab Report Essay

The purpose of this lab was to test the biological activity of ConA by performing a hemagglutination assay. If ConA is active then agglutination will occur due to ConA’s free receptors being able to bind to the glucose residues on the sheep’s red blood cells. If ConA is not active then no agglutination will occur. To test the hemagglutination reaction, two types of ConA solutions were compared, a purchased control ConA solution in buffer as the positive control, and a purified solution of ConA in buffer previously purified in lab. Each solution was at a 2mg/ml concentration of ConA in ConA buffer, which is necessary for ConA’s biological activity. Two variables were added, Galactose and Mannose, to the ConA solution to compare the effects each had on the hemagglutination reaction. I hypothesize for ConA to be able to agglutinate the red blood cells if in the adequate concentration and if in the presence of Galactose, not Mannose. Mannose will inhibit the ConA fro m binding to the red blood cell’s membrane, preventing agglutination. RESULTS The reaction plate containing the ConA dilutions was incubated over the weekend and resulted in all wells being pink, appearing as if every well had agglutinated. There was a vague outline of the non-agglutinated cells in various wells. The last agglutination was observed at titer 0.0625 (1/16). Agglutination was seen in rows A, B D, and E (row A contained the control ConA, row B contained the control ConA + Galactose, row D contained the sample ConA, and row E contained the sample ConA + Galactose). In the well rows C and F which contained control ConA + Mannose and sample ConA + Mannose, agglutination did not occur at any concentration of ConA. Row G, the negative control appeared to have agglutinated as well as Row H, which contained only ConA buffer. DISCUSSION AND CONCLUSION The results did not support my hypothesis for the biological activity of ConA. There are some sources of error that could explain the results obtained. It’s possible there was a problem with either the ConA buffer or the sheep red blood cells to allow for all wells to turn pink and appear agglutinated. Another explanation of the irregular results was there might have been cross contamination from not changing tips when transferring to different ConA concentrations, or if bubbles were introduced while diluting the ConA, making the results difficult to interpret. For wells A, B D, and E as ConA became more diluted or decreased in concentration, it became more difficult for it to effectively crosslink and agglutinate the red blood cells. Well D, the positive control that contained the purchased ConA resulted in agglutination of the first couple wells, then no agglutination as the ConA concentration decreased, similar to Row A. Wells B and E that had the Galacatose additive obtained the same titer of the control ConA because ConA does not bind Galactose. Galactose doesn’t interfere with ConA from binding to the sugar residues on the red blood cells. Mannose on the other hand, is an inhibitor to ConA’s binding sites. The Mannose in solution competed with the ConA and did not allow to bind to the sugar residues on the red blood cells as seen in rows C and F. Row G, the negative control, should have resulted in non-agglutination, similar to the rows containing the Mannose additive. The results observed showed agglutination formed in this row. Lastly, Row H should have shown non-agglutination through out because the well contained only ConA buffer, not ConA protein. In conclusion, the results did not clearly explain the biological activity of ConA with the hemagglutination assay. The experiment contained too many anomalies to get a clear determination of ConA’s functionality post purification. The results did show that a change in the concentration of ConA would alter the strength of the reaction. Also, ConA’s ability to bind to sugar residues can be affected if ConA has to compete or is inhibited to bind to a cells membrane. LITERATURE CITED Cell Biology 3822 Lab Manual, Cell Surface Glycoprotein Receptor Analysis Using Concanavalin A Lab 7. Pearson Learning Solutions. 2012: 147-154. Madeleine Zaechringer. Cell Biology 3822 Analysis of purified ConA via Hemagglutinatino Assay Lab 7: Powerpoint. 2014.

Behavioral Finance

Behavioral finance is a study which involves the influence of psychology on the attitudes and behavior of investors and its subsequent effects on the markets. Behavioral Studies is still in its development stages, but it is instrumental in determining/ explaining as to why or how markets might be inefficient. The difference between traditional finance and behavioral finance is that traditional finance is based on the following concepts: – Investors have rational behavior – Capital Asset Pricing Model (CAPM) – Markets are efficientBehavioral finance on the other hand says that, the psychological forces interfere with these concepts. It says that there are both internal and external behavioral obstacles towards the value creation of any company. In practical terms it brings forward the errors in judgments made by both individual investors and fund managers and the various biases to which we as humans are prone. Analyzing this will place us in a position to make dec isions which avoid errors/mistakes committed in the past . INVESTORS: Individual investors: An individual investor is a person who purchases small amounts of securities for him/herself.He is not professionally involved in investment services and whatever purchases he/she makes are on an arm’s length basis. Individual investors are highly regulated because they are thought of as amateurs with little or no knowledge. An individual investor is also known as retail investor or small investor . Professional investor: These investors are usually all those businesses which are involved in giving investment services either directly or indirectly for example, investment companies, mutual funds, investment banks, brokerage houses etc.Besides them professional investors could also be individuals which are professionally involved in giving investment services. Professional investors are also known as institutional investors. These investors are subject to fewer regulations probably becau se they are perceived as having superior knowledge to individual investors . Behavioral biases: Individual and Institutional investors are both prone to almost similar biases, because institutional investors are although organizations in their own right but in actual are lead by a handful of managers.Proponents of this study argue that humans are prone to bias in making their judgments no matter how qualified or experienced they may be. They say that humans make frequent use of heuristics, mental shortcuts/rules of thumb to simplify decisions and tasks that are complex. Availability heuristic: With availability heuristic it is believed that for humans the probability of an event occurring is dependent on how easily one can imagine that event happening. The more clear is the image the greater the probability.A related concept is Illusory correlation which describes we imagine and hence interpret evidence. Although this bias is limited for retail investors since not only their investm ents are smaller but they also don’t have various charts, patterns analyzing past year data at their disposal, as for institutional investors this bias is at a much more magnified level because many fund managers use charts and technical analysis which according to them helps in identifying various patterns and price/stock moments . Representativeness heuristic:This concept says that humans are prone making judgments that involve consideration of stereo-types instead of the underlying features. For example, while hiring the selection process takes into consideration the qualifications, relevant experience, personality etc. however this in no way can predict the future job performance of the individual. This also incorporates a related concept called Illusion of validity which puts forward that the confidence in one’s judgment is primarily based on the representation of the situation instead of the characteristics.However, retail investors are more prone to this bias as compared to institutional investors because they have the information that is available to the general public for example, commentaries from financial journalists, analysts which believe that well known companies are good stock-market investment options, but in reality these two factors are largely unrelated . Anchoring and adjustment: This is another important heuristic according to which decisions made by humans are dependent on some key value/number.There is no process or logic behind determination of this value/number it could be any random number. For example, budgeting which involves use of current figures to determine future estimates. Many fund managers use current year figures and current year industry averages to determine future estimates. This bias is a product of our inherent conservatism which leads to our under reaction to new information. Institutional investors are more prone to this bias as compared to small investors. Probably because the managers of investment c ompanies actively use these techniques to draw conclusions.Small investors would hardly be aware so these techniques however those with an accounting background could be an exception . Loss aversion: It is also a key bias. It is based on the concept that humans find it very difficult to accept loss and the state of denial is such that we infact believe that holding onto it for longer periods of time would turnaround things some way or the other. This bias has some major consequences in financial decision-making. For instance, over the years it has been seen that many companies have kept running loss-making units and destroying shareholder wealth to the level at which it was irreparable.The reasons behind the strength of this bias as scholars put it is the shame and regret and feeling the blame for the loss incurred. Individual investors are more prone to this professional investors, a study revealed that individual investors sell those stocks that start to perform well quite soon an d hang on loss-making stocks for longer periods of time hoping that things might take a u-turn. This problem as professional traders put it is named get evenitis. Hindsight bias: It is based on the concept that humans are prone to that feeling â€Å"I knew it all the while† or precisely hindsight bias.To correct this bias is also very difficult because it’s natural for us to make differing conclusions regarding what happened in the past even though those decisions would have been correct according to the data and circumstances at hand then. For example, these days since the global economy is in recession even a layman is heard that this was inevitable. Individual investors are prone to this bias out of human nature, as for institutional investors they are less prone to this because they would be having greater access to information all the time .Over-confidence bias: Humans are naturally over-confident about their abilities normally. This further leads to over optimism i. e. we normally feel that we can be successful in most of our endeavors or do the right thing in most of the situations. However in reality that is not possible. Moreover the more information or data one gathers regarding a task, the more that person feels in greater control this is called Illusion of knowledge. Practically the biggest setback that one has to deal with results unfolds is that they are quite different than what was expected.Individual investors are much less prone to this bias as compared to institutional investors which suffer a lot more, because the over-confidence of a team of managers would prove more lethal financially. For example, 3Com which acquired US Robotics in 2000 made an IPO of its division that made the famous Palm pilots. Although the share prices went as high as $165 making 3Com the fourth largest technology firm then but announcement of a forthcoming product without the infrastructure yet in place saw its share prices dramatically fall to $1. 35 in 2001.This financial blunder was a result of a combined over-optimism of the then senior management. INVESTMENT BELIEFS: Characteristics of the Individual investor’s investment beliefs would be focused on limited aspects probably because they have limited knowledge of the market and they invest smaller amounts as compared to institutional investors. They would probably invest in companies that have good market reputation and which promise a good return within a short span of time. As for institutional investors their investment beliefs would be diverse since they are professionals.It would be important for them to take measures to avoid conflicts of interest. It would also be important for them to develop a clear view of capital markets in order to invest in companies that are expected to yield good returns . CONCLUSION: Behavioral finance has therefore highlighted that financial decision-making of both individual and institutional investors. The errors/mistakes made in yes ter-years both at the individual and organizational level if taken care of in future could result in making sound long-term decisions. WORKS CITED: Blanco. A.Behavioral Finance Possibilities and Limitations of Different Approaches. Wiesbaden, 2003 Fortune. Why CEOs Fail. February 10th 2009 Retrieved from :< http://money. cnn. com/magazines/fortune/>, 1999. Goldberg. J. Behavioral Finance. John Wiley, 2001. Montier. J. Behavioral Finance: Insights into Irrational Minds and Markets. J. Wiley. 2002. Owen. A. S. Behavioral Finance and the Decision to Invest in High Tech Stocks. School of Finance and Economics, University of Technology, 2002 Pompian. M. M. Behavioral Finance and Wealth Management: How to Build Optimal Portfolios That Account for Investor Biases.John Wiley and Sons, 2006. Redhead. K. Personal Finance and Investments: A Behavioral Finance Perspective. Routledge, 2008 Shefrin. H. Behavioral Finance. Edward Elgar Pub, 2001. Shleifer . A. Inefficient Markets: An Introduction to Behavioral Finance. Oxford University Press US, 2000. Stanyer. P, Dimson. E. The Economist Guide to Investment Strategy: How to Understand Markets, Risk, Rewards and Behaviour. Bloomberg Press, 2006. Taffler. J. R. (2001). Management Focus. Thaler. H. R. (1993). Advances in Behavioral Finance. Russell Sage Foundation

Love Is A Powerful Feeling Essay - 1353 Words

Love is a powerful feeling; it makes you do crazy thing. Many people spend years trying to find it, others give up thinking they’ll never find it. Love has been defined as an intensive feeling of a deep romantic or sexual attachment to someone. Of course, Love doesn t have to romantic and/or sexual. People who are ace, as in asexual, aromantic and agender, can still be in relationships that are satisfying for them without the needs of a romantic relationship. Familial love is also non-romantic-sexual. However, in this paper, we will be talking about romantic-sexual love, what it is, and why I believe it’s so important to understand and experience. Like I mentioned in the paragraph above love is usually defined as an intensive feeling of a deep romantic or sexual attachment to someone, however love is a bit more complicated than that. Love is special, it’s unique in it’s attitude and behavioral components, it’s a phenomenon that eludes easy definitio n (Our Sexuality, 2012). Love has always been a complicated subject; sometimes love is fickle, sometimes love isn’t love, but rather pure infatuation. Infatuation is often mistaken for love, however it is only a short lived but intense passion for someone. It’s possible that since many infatuations are mistaken love that many researches regarding the measurements of love would include individuals infatuated with each other. In one possible case, a man named Zick Rubin wished to measure love and liking. He set up 13 questionsShow MoreRelatedTheme Of Sonnet 1161025 Words   |  5 PagesLove is an emotion and feeling that will either fade away as time goes by or stay with a person for a lifetime. Love is not only between opposite sexes but rather between the thought of humankind. 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